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Additionally, these participants achieve an HbA1c level of 7%

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Chen, S., Okahara, F., Osaki, N

this difference may result from a ~5x stronger effect produced by GLP-1 analogs, compared to DPP-4 inhibitors (Charbonnel & Cariou, 2011) No change in weight Contraindications: type I diabetes (these patients lack pancreatic beta cells) diabetic ketoacidosis (it would not be effective for treating this condition) an association between DPP-4 inhibitors and heart failure has been observed for two members of this drug class in patients with type 2 DM and atherosclerosis

PMID: 39175746 Last reviewed: June 14, 2026

N Engl J Med (2022) 387:20516